CATH Classification

Domain Context

CATH Clusters

Superfamily 2.60.120.1520
Functional Family Alkylated DNA repair protein alkB homolog 8

Enzyme Information

2.1.1.229
tRNA (carboxymethyluridine(34)-5-O)-methyltransferase.
based on mapping to UniProt Q96BT7
S-adenosyl-L-methionine + carboxymethyluridine(34) in tRNA = S-adenosyl- L-homocysteine + 5-(2-methoxy-2-oxoethyl)uridine(34) in tRNA.
-!- The enzyme catalyzes the posttranslational modification of uridine residues at the wobble position 34 of the anticodon loop of tRNA.
1.14.11.-
With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
based on mapping to UniProt Q96BT7

UniProtKB Entries (1)

Q96BT7
ALKB8_HUMAN
Homo sapiens
Alkylated DNA repair protein alkB homolog 8

PDB Structure

PDB 3THT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification.
Pastore, C., Topalidou, I., Forouhar, F., Yan, A.C., Levy, M., Hunt, J.F.
J.Biol.Chem.