CATH Classification

Domain Context

CATH Clusters

Superfamily Ubiquinol cytochrome reductase, transmembrane domain
Functional Family Cytochrome b-c1 complex subunit Rieske, mitochondrial

Enzyme Information

7.1.1.8
Quinol--cytochrome-c reductase.
based on mapping to UniProt Q5ZLR5
Quinol + 2 ferricytochrome c(Side 2) = quinone + 2 ferrocytochrome c(Side 2) + 2 H(+)(Side 2).
-!- The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain. -!- It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria. -!- The mammalian enzyme contains cytochromes b-562, b-566 and c(1), and a 2-iron ferredoxin. -!- Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non- cytoplasmic compartment (cf. EC 1.6.99.3). -!- Formerly EC 1.10.2.2.

UniProtKB Entries (1)

D0VX29
D0VX29_CHICK
Gallus gallus
Mitochondrial ubiquinol-cytochrome-c reductase complex core protein 2

PDB Structure

PDB 3TGU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Computational discovery of picomolar Q(o) site inhibitors of cytochrome bc1 complex.
Hao, G.F., Wang, F., Li, H., Zhu, X.L., Yang, W.C., Huang, L.S., Wu, J.W., Berry, E.A., Yang, G.F.
J.Am.Chem.Soc.