CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family Dehydrosqualene synthase

Enzyme Information

2.5.1.96
4,4'-diapophytoene synthase.
based on mapping to UniProt A9JQL9
2 (2E,6E)-farnesyl diphosphate = 15-cis-4,4'-diapophytoene + 2 diphosphate.
-!- Typical of Staphylococcus aureus and some other bacteria such as Heliobacillus sp.

UniProtKB Entries (1)

A9JQL9
CRTM_STAAU
Staphylococcus aureus
4,4'-diapophytoene synthase

PDB Structure

PDB 3TFP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Dual dehydrosqualene/squalene synthase inhibitors: leads for innate immune system-based therapeutics.
Lin, F.Y., Zhang, Y., Hensler, M., Liu, Y.L., Chow, O.A., Zhu, W., Wang, K., Pang, R., Thienphrapa, W., Nizet, V., Oldfield, E.
Chemmedchem