CATH Classification

Domain Context

CATH Clusters

Superfamily Probable tRNA modification gtpase trme; domain 1
Functional Family

Enzyme Information

2.1.1.269
Dimethylsulfoniopropionate demethylase.
based on mapping to UniProt Q4FP21
S,S-dimethyl-beta-propiothetin + tetrahydrofolate = 3-(methylthio)propanoate + 5-methyltetrahydrofolate.
-!- The enzyme from the marine bacteria Pelagibacter ubique and Ruegeria pomeroyi are specific toward S,S-dimethyl-beta-propiothetin. -!- They do not demethylate glycine-betaine.

UniProtKB Entries (1)

Q4FP21
DMDA_PELUB
Candidatus Pelagibacter ubique HTCC1062
Dimethylsulfonioproprionate demethylase DmdA

PDB Structure

PDB 3TFH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of dimethylsulfoniopropionate-dependent demethylase from the marine organism Pelagabacter ubique.
Schuller, D.J., Reisch, C.R., Moran, M.A., Whitman, W.B., Lanzilotta, W.N.
Protein Sci.