CATH Domain 3tdeA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.300	GMP Synthetase; Chain A, domain 3
	3.30.300.10

Domain Context

CATH Clusters

Superfamily	3.30.300.10
Functional Family	S-adenosylmethionine synthase

Enzyme Information

2.5.1.6

Methionine adenosyltransferase.

based on mapping to UniProt P9WGV1

ATP + L-methionine + H(2)O = phosphate + diphosphate + S-adenosyl-L- methionine.

-!- Formerly EC 2.4.2.13.

UniProtKB Entries (1)

METK_MYCTU

Mycobacterium tuberculosis H37Rv

S-adenosylmethionine synthase

PDB Structure

PDB	3TDE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Increasing the structural coverage of tuberculosis drug targets. Baugh, L., Phan, I., Begley, D.W., Clifton, M.C., Armour, B., Dranow, D.M., Taylor, B.M., Muruthi, M.M., Abendroth, J., Fairman, J.W., Fox, D., Dieterich, S.H., Staker, B.L., Gardberg, A.S., Choi, R., Hewitt, S.N., Napuli, A.J., Myers, J., Barrett, L.K., Zhang, Y., Ferrell, M., Mundt, E., Thompkins, K., Tran, N., Lyons-Abbott, S., Abramov, A., Sekar, A., Serbzhinskiy, D., Lorimer, D., Buchko, G.W., Stacy, R., Stewart, L.J., Edwards, T.E., Van Voorhis, W.C., Myler, P.J. Tuberculosis (Edinb)