CATH Domain 3tcpA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Tyrosine-protein kinase receptor TYRO3

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt Q12866

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q12866

MERTK_HUMAN

Homo sapiens

Tyrosine-protein kinase Mer

PDB Structure

PDB	3TCP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. Liu, J., Yang, C., Simpson, C., Deryckere, D., Van Deusen, A., Miley, M.J., Kireev, D., Norris-Drouin, J., Sather, S., Hunter, D., Korboukh, V.K., Patel, H.S., Janzen, W.P., Machius, M., Johnson, G.L., Earp, H.S., Graham, D.K., Frye, S.V., Wang, X. ACS Med Chem Lett