CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.270
Functional Family DNA polymerase IV

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q97W02
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q97W02
DPO4_SACS2
Saccharolobus solfataricus P2
DNA polymerase IV

PDB Structure

PDB 3T5H
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Replication bypass of the trans-4-Hydroxynonenal-derived (6S,8R,11S)-1,N(2)-deoxyguanosine DNA adduct by the sulfolobus solfataricus DNA polymerase IV.
Banerjee, S., Christov, P.P., Kozekova, A., Rizzo, C.J., Egli, M., Stone, M.P.
Chem.Res.Toxicol.