CATH Classification

Domain Context

CATH Clusters

Superfamily N-terminal domain of ligase-like
Functional Family

Enzyme Information

6.2.1.3
Long-chain-fatty-acid--CoA ligase.
based on mapping to UniProt P9WQ37
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
-!- Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. -!- The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24).

UniProtKB Entries (1)

P9WQ37
FAC13_MYCTU
Mycobacterium tuberculosis H37Rv
Long-chain-fatty-acid--CoA ligase FadD13

PDB Structure

PDB 3T5C
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular basis of the functional divergence of fatty acyl-AMP ligase biosynthetic enzymes of Mycobacterium tuberculosis.
Goyal, A., Verma, P., Anandhakrishnan, M., Gokhale, R.S., Sankaranarayanan, R.
J.Mol.Biol.