CATH Classification

Domain Context

CATH Clusters

Superfamily Alkaline Phosphatase, subunit A
Functional Family

Enzyme Information

3.6.1.9
Nucleotide diphosphatase.
based on mapping to UniProt Q92UV8
A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate.
-!- The enzyme preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates. -!- In vitro the enzyme also acts as a nucleotidohydrolase on ADP, NAD(+), NADP(+), FAD, and CoA. -!- Formerly EC 3.6.1.19.

UniProtKB Entries (1)

Q92UV8
Q92UV8_RHIME
Sinorhizobium meliloti 1021
Probable phosphonoacetate hydrolase

PDB Structure

PDB 3SZY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and mechanistic insights into C-p bond hydrolysis by phosphonoacetate hydrolase.
Agarwal, V., Borisova, S.A., Metcalf, W.W., van der Donk, W.A., Nair, S.K.
Chem.Biol.