CATH Classification

Domain Context

CATH Clusters

Superfamily Copper amine oxidase, catalytic domain
Functional Family Amine oxidase

Enzyme Information

1.4.3.21
Primary-amine oxidase.
based on mapping to UniProt P12807
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.

UniProtKB Entries (1)

P12807
AMO_PICAN
Ogataea angusta
Peroxisomal primary amine oxidase

PDB Structure

PDB 3SX1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The precursor form of Hansenula polymorpha copper amine oxidase 1 in complex with CuI and CoII.
Klema, V.J., Johnson, B.J., Klinman, J.P., Wilmot, C.M.
Acta Crystallogr.,Sect.F