CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family ATP-dependent Clp protease proteolytic subunit

Enzyme Information

3.4.21.92
Endopeptidase Clp.
based on mapping to UniProt P63786
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
-!- Belongs to peptidase family S14.

UniProtKB Entries (1)

P63786
CLPP_STAAW
Staphylococcus aureus subsp. aureus MW2
ATP-dependent Clp protease proteolytic subunit

PDB Structure

PDB 3ST9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural switching of Staphylococcus aureus Clp protease: a key to understanding protease dynamics
Zhang, J., Ye, F., Lan, L., Jiang, H., Luo, C., Yang, C.-G.
J.Biol.Chem.