CATH Classification

Domain Context

CATH Clusters

Superfamily Anthranilate synthase
Functional Family Salicylate synthase

Enzyme Information

4.2.99.21
Isochorismate lyase.
based on mapping to UniProt P9WFX1
Isochorismate = salicylate + pyruvate.
-!- This enzyme is part of the pathway of salicylate formation from chorismate, and forms an integral part of pathways that produce salicylate-derived siderophores, such as pyochelin and yersiniabactin.
5.4.99.5
Chorismate mutase.
based on mapping to UniProt P9WFX1
Chorismate = prephenate.
5.4.4.2
Isochorismate synthase.
based on mapping to UniProt P9WFX1
Chorismate = isochorismate.
-!- The reaction is reversible. -!- Formerly EC 5.4.99.6.

UniProtKB Entries (1)

P9WFX1
MBTI_MYCTU
Mycobacterium tuberculosis H37Rv
Salicylate synthase

PDB Structure

PDB 3ST6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis
Chi, G., Manos-Turvey, A., O'Connor, P.D., Johnston, J.M., Evans, G.L., Baker, E.N., Payne, R.J., Lott, J.S., Bulloch, E.M.
Biochemistry