CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Transmembrane protease serine

Enzyme Information

3.4.21.27
Coagulation factor XIa.
based on mapping to UniProt P03951
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa.
-!- The proenzyme XI is activated by EC 3.4.21.38. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P03951
FA11_HUMAN
Homo sapiens
Coagulation factor XI

PDB Structure

PDB 3SOR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors.
Fradera, X., Kazemier, B., Carswell, E., Cooke, A., Oubrie, A., Hamilton, W., Dempster, M., Krapp, S., Nagel, S., Jestel, A.
Acta Crystallogr.,Sect.F