CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Serine/threonine-protein kinase receptor

Enzyme Information

2.7.11.30
Receptor protein serine/threonine kinase.
based on mapping to UniProt P27037
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P27037
AVR2A_HUMAN
Homo sapiens
Activin receptor type-2A

PDB Structure

PDB 3SOC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin
Chaikuad, A., Williams, E., Mahajan, P., Cooper, C.D.O., Sanvitale, C., Vollmar, M., Muniz, J.R.C., Yue, W.W., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
To be Published