CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.420.40
Functional Family Acetate kinase

Enzyme Information

2.7.2.1
Acetate kinase.
based on mapping to UniProt P63411
ATP + acetate = ADP + acetyl phosphate.
-!- While purified enzyme from Escherichia coli is specific for acetate, others have found that the enzyme can also use propanoate as a substrate, but more slowly. -!- Acetate can be converted into the key metabolic intermediate acetyl- CoA by coupling acetate kinase with EC 2.3.1.8. -!- Both this enzyme and EC 2.7.2.15 play important roles in the production of propanoate.

UniProtKB Entries (1)

P63411
ACKA_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Acetate kinase

PDB Structure

PDB 3SLC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and mechanistic investigations on Salmonella typhimurium acetate kinase (AckA): identification of a putative ligand binding pocket at the dimeric interface
Chittori, S., Savithri, H.S., Murthy, M.R.N.
Bmc Struct.Biol.