CATH Classification

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family Phosphodiesterase

Enzyme Information

3.1.4.35
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt O76074
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

O76074
PDE5A_HUMAN
Homo sapiens
CGMP-specific 3',5'-cyclic phosphodiesterase

PDB Structure

PDB 3SHY
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors.
Xu, Z., Liu, Z., Chen, T., Chen, T.T., Wang, Z., Tian, G., Shi, J., Wang, X., Lu, Y., Yan, X., Wang, G., Jiang, H., Chen, K., Wang, S., Xu, Y., Shen, J., Zhu, W.
J.Med.Chem.