CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family MAP kinase-activated protein kinase 3

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q16644
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q16644
MAPK3_HUMAN
Homo sapiens
MAP kinase-activated protein kinase 3

PDB Structure

PDB 3SHE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series.
Oubrie, A., Kaptein, A., de Zwart, E., Hoogenboom, N., Goorden, R., van de Kar, B., van Hoek, M., de Kimpe, V., van der Heijden, R., Borsboom, J., Kazemier, B., de Roos, J., Scheffers, M., Lommerse, J., Schultz-Fademrecht, C., Barf, T.
Bioorg.Med.Chem.Lett.