CATH Classification

Domain Context

CATH Clusters

Superfamily KEN domain
Functional Family Serine/threonine-protein kinase/endoribonuclease IRE1

Enzyme Information

3.1.26.-
Endoribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt P32361
2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P32361
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P32361
IRE1_YEAST
Saccharomyces cerevisiae S288C
Serine/threonine-protein kinase/endoribonuclease IRE1

PDB Structure

PDB 3SDJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and functional basis for RNA cleavage by Ire1.
Korennykh, A.V., Korostelev, A.A., Egea, P.F., Finer-Moore, J., Stroud, R.M., Zhang, C., Shokat, K.M., Walter, P.
Bmc Biol.