CATH Classification

Domain Context

CATH Clusters

Superfamily Penicillin Amidohydrolase, domain 1
Functional Family

Enzyme Information

3.5.1.93
Glutaryl-7-aminocephalosporanic-acid acylase.
based on mapping to UniProt P07662
(7R)-7-(4-carboxybutanamido)cephalosporanate + H(2)O = (7R)-7- aminocephalosporanate + glutarate.
-!- Forms 7-aminocephalosporanic acid, a key intermediate in the synthesis of cephem antibiotics. -!- It reacts only weakly with cephalosporin C.

UniProtKB Entries (1)

P07662
G7AC_PSEU7
Pseudomonas sp. SY-77-1
Glutaryl-7-aminocephalosporanic-acid acylase

PDB Structure

PDB 3S8R
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of glutaryl 7-aminocephalosporanic acid acylase: insight into autoproteolytic activation.
Kim, J.K., Yang, I.S., Rhee, S., Dauter, Z., Lee, Y.S., Park, S.S., Kim, K.H.
Biochemistry