CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclodipeptide synthase
Functional Family Cyclo(L-leucyl-L-leucyl) synthase

Enzyme Information

2.3.2.22
Cyclo(L-leucyl-L-leucyl) synthase.
based on mapping to UniProt Q65EX3
2 L-leucyl-tRNA(Leu) = 2 tRNA(Leu) + cyclo(L-leucyl-L-leucyl).
-!- The reaction proceeds following a ping-pong mechanism forming a covalent intermediate between an active site serine and the first L-leucine residue. -!- The proteins from bacteria of the genus Bacillus also form small amounts of cyclo(L-phenylalanyl-L-leucyl) and cyclo(L-leucyl-L- methionyl).

UniProtKB Entries (1)

Q65EX3
CDLS_BACLD
Bacillus licheniformis DSM 13 = ATCC 14580
Cyclo(L-leucyl-L-leucyl) synthase

PDB Structure

PDB 3S7T
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for nonribosomal peptide synthesis by an aminoacyl-tRNA synthetase paralog.
Bonnefond, L., Arai, T., Sakaguchi, Y., Suzuki, T., Ishitani, R., Nureki, O.
Proc.Natl.Acad.Sci.USA