CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Catechol O-methyltransferase

Enzyme Information

2.1.1.6
Catechol O-methyltransferase.
based on mapping to UniProt P22734
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.
-!- The mammalian enzymes act more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.

UniProtKB Entries (1)

P22734
COMT_RAT
Rattus norvegicus
Catechol O-methyltransferase

PDB Structure

PDB 3S68
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Catechol-O-methyltransferase in complex with substituted 3'-deoxyribose bisubstrate inhibitors
Ellermann, M., Lerner, C., Burgy, G., Ehler, A., Bissantz, C., Jakob-Roetne, R., Paulini, R., Allemann, O., Tissot, H., Grunstein, D., Stihle, M., Diederich, F., Rudolph, M.G.
Acta Crystallogr.,Sect.D