CATH Classification

Domain Context

CATH Clusters

Superfamily Transglutaminase-like
Functional Family

Enzyme Information

2.3.2.13
Protein-glutamine gamma-glutamyltransferase.
based on mapping to UniProt P21980
A protein-L-glutamine + a protein-L-lysine = a protein with an N(6)- (gamma-glutamyl)-L-lysine cross-link + NH(3).
-!- The gamma-carboxymide groups of peptide-bound glutamine residues act as acyl donors, and the 6-amino-groups of protein- and peptide-bound lysine residues act as acceptors, to give intra- and inter-molecular N(6)-(5-glutamyl)lysine cross-links.

UniProtKB Entries (1)

P21980
TGM2_HUMAN
Homo sapiens
Protein-glutamine gamma-glutamyltransferase 2

PDB Structure

PDB 3S3S
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibitors of Transglutaminase 2: A therapeutic option in celiac disease
Lindemann, I., Boettcher, J., Oertel, K., Weber, J., Hils, M., Pasternack, R., Heine, A., Klebe, G.
To be Published