CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt E5KIY2
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

E5KIY2
E5KIY2_ECOLX
Escherichia coli
Beta-lactamase

PDB Structure

PDB 3S0Z
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A structural view of the antibiotic degradation enzyme NDM-1 from a superbug.
Guo, Y., Wang, J., Niu, G., Shui, W., Sun, Y., Zhou, H., Zhang, Y., Yang, C., Lou, Z., Rao, Z.
Protein Cell