CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.80 | Trefoil |
|
2.80.10 | Trefoil (Acidic Fibroblast Growth Factor, subunit A) |
|
2.80.10.50 |
Domain Context
CATH Clusters
| Superfamily | 2.80.10.50 |
| Functional Family | Ricin |
Enzyme Information
| 3.2.2.22 |
rRNA N-glycosylase.
based on mapping to UniProt P02879
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.
|
UniProtKB Entries (1)
| P02879 |
RICI_RICCO
Ricinus communis
Ricin
|
PDB Structure
| PDB | 3RTJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
X-ray analysis of substrate analogs in the ricin A-chain active site.
J.Mol.Biol.
|
