CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Beta-secretase 1

Enzyme Information

3.4.23.46
Memapsin 2.
based on mapping to UniProt P56817
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu- Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
-!- Suggested to be the major 'beta-secretase' responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. -!- Belongs to peptidase family A1.

UniProtKB Entries (1)

P56817
BACE1_HUMAN
Homo sapiens
Beta-secretase 1

PDB Structure

PDB 3RTH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
From Fragment Screening to In Vivo Efficacy: Optimization of a Series of 2-Aminoquinolines as Potent Inhibitors of Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1).
Cheng, Y., Judd, T.C., Bartberger, M.D., Brown, J., Chen, K., Fremeau, R.T., Hickman, D., Hitchcock, S.A., Jordan, B., Li, V., Lopez, P., Louie, S.W., Luo, Y., Michelsen, K., Nixey, T., Powers, T.S., Rattan, C., Sickmier, E.A., St Jean, D.J., Wahl, R.C., Wen, P.H., Wood, S.
J.Med.Chem.