CATH Classification

Domain Context

CATH Clusters

Superfamily Histone deacetylase domain
Functional Family Histone deacetylase 8

Enzyme Information

3.5.1.98
Histone deacetylase.
based on mapping to UniProt Q9BY41
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
-!- A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on a histone. -!- The reaction of this enzyme is opposite to that of EC 2.3.1.48. -!- Histone deacetylases (HDACs) can be organized into three classes depending on sequence similarity and domain organization. -!- Histone acetylation plays an important role in regulation of gene expression. -!- In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. -!- May be identical to EC 3.5.1.17.

UniProtKB Entries (1)

Q9BY41
HDAC8_HUMAN
Homo sapiens
Histone deacetylase 8

PDB Structure

PDB 3RQD
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases.
Cole, K.E., Dowling, D.P., Boone, M.A., Phillips, A.J., Christianson, D.W.
J.Am.Chem.Soc.