CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.10
Functional Family Chitinase 3-like 1

Enzyme Information

3.2.1.14
Chitinase.
based on mapping to UniProt Q9BZP6
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

Q9BZP6
CHIA_HUMAN
Homo sapiens
Acidic mammalian chitinase

PDB Structure

PDB 3RME
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Identification and Characterization of Acidic Mammalian Chitinase Inhibitors
Cole, D.C., Olland, A.M., Jacob, J., Brooks, J., Bursavich, M.G., Czerwinski, R., Declercq, C., Johnson, M., Joseph-McCarthy, D., Ellingboe, J.W., Lin, L., Nowak, P., Presman, E., Strand, J., Tam, A., Williams, C.M.M., Yao, S., Tsao, D.H.H., Fitz, L.J.
J.Med.Chem.