CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.920
Functional Family Transketolase

Enzyme Information

2.2.1.1
Transketolase.
based on mapping to UniProt P9WG25
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate.
-!- Wide specificity for both reactants, e.g. converts hydroxypyruvate and R-CHO into CO(2) and R-CHOH-CO-CH(2)OH. -!- The enzyme from the bacterium Alcaligenes faecalis shows high activity with D-erythrose 4-phosphate as acceptor.

UniProtKB Entries (1)

P9WG25
TKT_MYCTU
Mycobacterium tuberculosis H37Rv
Transketolase

PDB Structure

PDB 3RIM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme.
Fullam, E., Pojer, F., Bergfors, T., Jones, T.A., Cole, S.T.
Open Biol