CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase C12, ubiquitin carboxyl-terminal hydrolase
Functional Family Ubiquitin carboxyl-terminal hydrolase

Enzyme Information
Ubiquitinyl hydrolase 1.
based on mapping to UniProt Q9Y5K5
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

Homo sapiens
Ubiquitin carboxyl-terminal hydrolase isozyme L5

PDB Structure

External Links
Primary Citation
Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme.
Maiti, T.K., Permaul, M., Boudreaux, D.A., Mahanic, C., Mauney, S., Das, C.
Febs J.