CATH Classification

Domain Context

CATH Clusters

Superfamily 5' to 3' exonuclease, C-terminal subdomain
Functional Family Mutant DNA polymerase beta

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P06746
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
4.2.99.-
Other carbon-oxygen lyases.
based on mapping to UniProt P06746

UniProtKB Entries (1)

P06746
DPOLB_HUMAN
Homo sapiens
DNA polymerase beta

PDB Structure

PDB 3RH6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular insights into DNA polymerase deterrents for ribonucleotide insertion.
Cavanaugh, N.A., Beard, W.A., Batra, V.K., Perera, L., Pedersen, L.G., Wilson, S.H.
J.Biol.Chem.