CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Uronate dehydrogenase

Enzyme Information

1.1.1.203
Uronate dehydrogenase.
based on mapping to UniProt Q7CRQ0
(1) Beta-D-galacturonate + NAD(+) = D-galactaro-1,5-lactone + NADH. (2) Beta-D-glucuronate + NAD(+) = D-glucaro-1,5-lactone + NADH.
-!- The enzyme, characterized from the bacterium Agrobacterium fabrum, participates in oxidative degradation pathways for galacturonate and glucuronate. -!- The enzyme can only accept the beta anomeric form of the substrate. -!- The 1,5 lactone product is rather stable at cytosolic pH and does not hydrolyze spontaneously at a substantial rate. -!- Formerly EC 1.2.1.35.

UniProtKB Entries (1)

Q7CRQ0
URODH_AGRFC
Agrobacterium fabrum str. C58
Uronate dehydrogenase

PDB Structure

PDB 3RFT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Uronate Dehydrogenase from Agrobacterium tumefaciens.
Parkkinen, T., Boer, H., Janis, J., Andberg, M., Penttila, M., Koivula, A., Rouvinen, J.
J.Biol.Chem.