CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.450 | Nuclear Transport Factor 2; Chain: A, |
|
3.10.450.60 |
Domain Context
CATH Clusters
| Superfamily | 3.10.450.60 |
| Functional Family |
Enzyme Information
| 1.13.11.31 |
Arachidonate 12-lipoxygenase.
based on mapping to UniProt P16469
Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa- 5,8,10,14-tetraenoate.
-!- The product is rapidly reduced to the corresponding 12S-hydroxy compound.
|
| 1.13.11.33 |
Arachidonate 15-lipoxygenase.
based on mapping to UniProt P16469
Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa- 5,8,11,13-tetraenoate.
-!- The product is rapidly converted to the corresponding 15S-hydroxy compound.
|
UniProtKB Entries (1)
| P16469 |
LOX15_PIG
Sus scrofa
Arachidonate 15-lipoxygenase
|
PDB Structure
| PDB | 3RDE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of 12-lipoxygenase catalytic-domain-inhibitor complex identifies a substrate-binding channel for catalysis.
Structure
|