CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.1.1.384
dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase.
based on mapping to UniProt B3TMR8
dTDP-4-dehydro-2,6-dideoxy-alpha-D-glucose + NADP(+) = dTDP-3,4- didehydro-2,6-dideoxy-alpha-D-glucose + NADPH.
-!- The enzyme is involved in the biosynthesis of several deoxysugars, including L-digitoxose, L- and D-olivose, L-oliose, D-mycarose and forosamine.

UniProtKB Entries (1)

B3TMR8
KIJDR_ACTKI
Actinomadura kijaniata
DTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase

PDB Structure

PDB 3RC2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Combined Structural and Functional Investigation of a C-3''-Ketoreductase Involved in the Biosynthesis of dTDP-l-Digitoxose.
Kubiak, R.L., Holden, H.M.
Biochemistry