CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family Serine--pyruvate aminotransferase

Enzyme Information

2.6.1.51
Serine--pyruvate transaminase.
based on mapping to UniProt P21549
L-serine + pyruvate = 3-hydroxypyruvate + L-alanine.
-!- The liver enzyme may be identical with EC 2.6.1.44.
2.6.1.44
Alanine--glyoxylate transaminase.
based on mapping to UniProt P21549
L-alanine + glyoxylate = pyruvate + glycine.
-!- With one component of the animal enzyme, 2-oxobutanoate can replace glyoxylate. -!- A second component also catalyzes the reaction of EC 2.6.1.51.

UniProtKB Entries (1)

P50542
PEX5_HUMAN
Homo sapiens
Peroxisomal targeting signal 1 receptor

PDB Structure

PDB 3R9A
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1
Fodor, K., Wolf, J., Erdmann, R., Schliebs, W., Wilmanns, M.
Plos Biol.