CATH Classification

Domain Context

CATH Clusters

Superfamily Glutaredoxin
Functional Family Glutathione S-transferase, omega

Enzyme Information

1.8.5.7
Glutathionyl-hydroquinone reductase.
based on mapping to UniProt P42620
Glutathione + 2-(glutathione-S-yl)-hydroquinone = glutathione disulfide + hydroquinone.
-!- This type of enzymes, which are found in bacteria, halobacteria, fungi, and plants, catalyze the glutathione-dependent reduction of glutathionyl-hydroquinones. -!- The enzyme from the bacterium Sphingobium chlorophenolicum can act on halogenated substrates such as 2,6-dichloro-3-(glutathione-S-yl)- hydroquinone and 2,3,5-trichloro-6-(glutathione-S-yl)-hydroquinone. -!- Substrates for these enzymes are often formed spontaneously by interaction of benzoquinones with glutathione.

UniProtKB Entries (1)

P42620
YQJG_ECOLI
Escherichia coli K-12
Glutathionyl-hydroquinone reductase YqjG

PDB Structure

PDB 3R3E
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure Analysis of yqjG from Escherichia Coli K-12
Branch, M.C., Cook, P.D., Harp, J.M., Armstrong, R.N.
To be Published