CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Cyclin-dependent kinase 5 homolog

Enzyme Information

2.7.11.22
Cyclin-dependent kinase.
based on mapping to UniProt P24941
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P24941
CDK2_HUMAN
Homo sapiens
Cyclin-dependent kinase 2

PDB Structure

PDB 3R1Q
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-guided optimization of novel CDK2 inhibitors discovered by high-throughput screening
Schonbrunn, E., Becker, A., Betzi, S., Alam, R., Han, H., Rawle, F., Katta, V., Jakkaraj, J., Chakrasali, R., Neelam, S., Hook, D., Tash, J., Georg, G.
To be Published