CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1100
Functional Family D-serine dehydratase

Enzyme Information

4.3.1.18
D-serine ammonia-lyase.
based on mapping to UniProt Q8ZL08
D-serine = pyruvate + NH(3).
-!- The enzyme cleaves a carbon-oxygen bond, releasing a water molecule (hence the enzyme's original classification as EC 4.2.1.14) and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. -!- The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10. -!- Also acts, slowly, on D-threonine. -!- Formerly EC 4.2.1.14.

UniProtKB Entries (1)

Q8ZL08
SDHD_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
D-serine dehydratase

PDB Structure

PDB 3R0Z
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of open and closed forms of D-serine deaminase from Salmonella typhimurium - implications on substrate specificity and catalysis
Bharath, S.R., Bisht, S., Savithri, H.S., Murthy, M.R.N.
Febs J.