CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.1740.10
Functional Family 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Enzyme Information

1.1.1.267
1-deoxy-D-xylulose-5-phosphate reductoisomerase.
based on mapping to UniProt P45568
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
-!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction.

UniProtKB Entries (1)

P45568
DXR_ECOLI
Escherichia coli K-12
1-deoxy-D-xylulose 5-phosphate reductoisomerase

PDB Structure

PDB 3R0I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Reverse Fosmidomycin Derivatives against the Antimalarial Drug Target IspC (Dxr).
Behrendt, C.T., Kunfermann, A., Illarionova, V., Matheeussen, A., Pein, M.K., Grawert, T., Kaiser, J., Bacher, A., Eisenreich, W., Illarionov, B., Fischer, M., Maes, L., Groll, M., Kurz, T.
J.Med.Chem.