CATH Classification

Domain Context

CATH Clusters

Superfamily Tetratricopeptide repeat domain
Functional Family N-lysine methyltransferase SMYD2 isoform X2

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q8R5A0
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
2.1.1.-
Methyltransferases.
based on mapping to UniProt Q8R5A0

UniProtKB Entries (1)

Q8R5A0
SMYD2_MOUSE
Mus musculus
N-lysine methyltransferase SMYD2

PDB Structure

PDB 3QWV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of histone and p53 methyltransferase SmyD2 reveal a conformational flexibility of the autoinhibitory C-terminal domain.
Jiang, Y., Sirinupong, N., Brunzelle, J., Yang, Z.
Plos One