CATH Classification

Domain Context

CATH Clusters

Superfamily Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family Quinone oxidoreductase 1

Enzyme Information

1.6.5.5
NADPH:quinone reductase.
based on mapping to UniProt P38230
NADPH + 2 quinone = NADP(+) + 2 semiquinone.
-!- Specific for NADPH. -!- Catalyzes the one-electron reduction of certain quinones, with the orthoquinones 1,2-naphthoquinone and 9,10-phenanthrenequinone being the best substrates. -!- Dicoumarol (cf. EC 1.6.5.2) and nitrofurantoin are competitive inhibitors with respect to the quinone substrate. -!- The semiquinone free-radical product may be non-enzymically reduced to the hydroquinone or oxidized back to quinone in the presence of O(2). -!- Abundant in the lens of the eye of some mammalian species.

UniProtKB Entries (1)

P38230
QOR_YEAST
Saccharomyces cerevisiae S288C
Probable quinone oxidoreductase

PDB Structure

PDB 3QWA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural insights into the cofactor-assisted substrate recognition of yeast quinone oxidoreductase Zta1
Guo, P.C., Ma, X.X., Bao, Z.Z., Ma, J.D., Chen, Y., Zhou, C.Z.
J.Struct.Biol.