CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase receptor TYRO3

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P55144
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P55144
TYRO3_MOUSE
Mus musculus
Tyrosine-protein kinase receptor TYRO3

PDB Structure

PDB 3QUP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel and selective spiroindoline-based inhibitors of sky kinase.
Powell, N.A., Kohrt, J.T., Filipski, K.J., Kaufman, M., Sheehan, D., Edmunds, J.E., Delaney, A., Wang, Y., Bourbonais, F., Lee, D.Y., Schwende, F., Sun, F., McConnell, P., Catana, C., Chen, H., Ohren, J., Perrin, L.A.
Bioorg.Med.Chem.Lett.