CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.260.60
Functional Family Histone-lysine N-methyltransferase, H3 lysine-79 specific

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q8TEK3
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q8TEK3
DOT1L_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase, H3 lysine-79 specific

PDB Structure

PDB 3QOX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Chemogenetic analysis of human protein methyltransferases.
Richon, V.M., Johnston, D., Sneeringer, C.J., Jin, L., Majer, C.R., Elliston, K., Jerva, L.F., Scott, M.P., Copeland, R.A.
Chem.Biol.Drug Des.