CATH Classification

Domain Context

CATH Clusters

Superfamily Bira Bifunctional Protein; Domain 2
Functional Family Seryl-tRNA synthetase, cytoplasmic

Enzyme Information

6.1.1.11
Serine--tRNA ligase.
based on mapping to UniProt Q9HGT6
(1) ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). (2) ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).
-!- This enzyme also recognizes tRNA(Sec), the special tRNA for selenocysteine, and catalyzes the formation of L-seryl-tRNA(Sec), the substrate for EC 2.9.1.1.

UniProtKB Entries (1)

Q9HGT6
SYSC_CANAL
Candida albicans SC5314
Serine--tRNA ligase, cytoplasmic

PDB Structure

PDB 3QO8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen.
Rocha, R., Pereira, P.J., Santos, M.A., Macedo-Ribeiro, S.
Proc.Natl.Acad.Sci.USA