CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt Q7BNC2
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

Q7BNC2
Q7BNC2_ECOLX
Escherichia coli
Beta-lactamase

PDB Structure

PDB 3QNC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D {beta}-lactamase OXA-10 by rational protein design.
De Luca, F., Benvenuti, M., Carboni, F., Pozzi, C., Rossolini, G.M., Mangani, S., Docquier, J.D.
Proc.Natl.Acad.Sci.USA