CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Sorbitol dehydrogenase

Enzyme Information

1.1.1.9
D-xylulose reductase.
based on mapping to UniProt P07846
Xylitol + NAD(+) = D-xylulose + NADH.
-!- Also acts as an L-erythrulose reductase.
1.1.1.14
L-iditol 2-dehydrogenase.
based on mapping to UniProt P07846
L-iditol + NAD(+) = L-sorbose + NADH.
-!- This enzyme is widely distributed and has been described in archaea, bacteria, yeast, plants and animals. -!- It acts on a number of sugar alcohols, including (but not limited to) L-iditol, D-glucitol, D-xylitol, and D-galactitol. -!- Enzymes from different organisms or tissues display different substrate specificity. -!- The enzyme is specific to NAD(+) and can not use NADP(+).
1.1.1.-
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt P07846

UniProtKB Entries (1)

P07846
DHSO_SHEEP
Ovis aries
Sorbitol dehydrogenase

PDB Structure

PDB 3QE3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-ray crystal structure and small-angle X-ray scattering of sheep liver sorbitol dehydrogenase.
Yennawar, H., Moller, M., Gillilan, R., Yennawar, N.
Acta Crystallogr.,Sect.D