CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.420.40
Functional Family

Enzyme Information

2.7.1.170
Anhydro-N-acetylmuramic acid kinase.
based on mapping to UniProt Q9I5Q5
ATP + 1,6-anhydro-N-acetyl-beta-muramate + H(2)O = ADP + N-acetylmuramate 6-phosphate.
-!- This enzyme, along with EC 4.2.1.126, is required for the utilization of anhydro-N-acetylmuramic acid in proteobacteria. -!- The substrate is either imported from the medium or derived from the bacterium's own cell wall murein during cell wall recycling. -!- The product N-acetylmuramate 6-phosphate is produced as a 7:1 mixture of the alpha- and beta-anomers. -!- Formerly EC 2.7.1.n1.

UniProtKB Entries (1)

Q9I5Q5
ANMK_PSEAE
Pseudomonas aeruginosa PAO1
Anhydro-N-acetylmuramic acid kinase

PDB Structure

PDB 3QBX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular Basis of 1,6-Anhydro Bond Cleavage and Phosphoryl Transfer by Pseudomonas aeruginosa 1,6-Anhydro-N-acetylmuramic Acid Kinase.
Bacik, J.P., Whitworth, G.E., Stubbs, K.A., Yadav, A.K., Martin, D.R., Bailey-Elkin, B.A., Vocadlo, D.J., Mark, B.L.
J.Biol.Chem.