CATH Classification

Domain Context

CATH Clusters

Superfamily Histone deacetylase domain
Functional Family

Enzyme Information

3.5.1.62
Acetylputrescine deacetylase.
based on mapping to UniProt Q48935
N-acetylputrescine + H(2)O = acetate + putrescine.
-!- The enzyme from Micrococcus luteus also acts on N(8)-acetylspermidine and acetylcadaverine, but more slowly.
3.5.1.48
Acetylspermidine deacetylase.
based on mapping to UniProt Q48935
N(8)-acetylspermidine + H(2)O = acetate + spermidine.
-!- It was initially thought that N(1)-acetylspermidine was the substrate for this deacetylase reaction but this has since been disproved.
3.5.1.-
In linear amides.
based on mapping to UniProt Q48935

UniProtKB Entries (1)

Q48935
APAH_MYCRA
Mycoplana ramosa
Acetylpolyamine amidohydrolase

PDB Structure

PDB 3Q9B
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of prokaryotic polyamine deacetylase reveals evolutionary functional relationships with eukaryotic histone deacetylases .
Lombardi, P.M., Angell, H.D., Whittington, D.A., Flynn, E.F., Rajashankar, K.R., Christianson, D.W.
Biochemistry