CATH Classification

Domain Context

CATH Clusters

Superfamily 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Functional Family 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Enzyme Information

4.6.1.12
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.
based on mapping to UniProt Q63T71
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = 2-C-methyl- D-erythritol 2,4-cyclodiphosphate + CMP.
-!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

Q63T71
ISPF_BURPS
Burkholderia pseudomallei K96243
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

PDB Structure

PDB 3Q8H
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei.
Zhang, Z., Jakkaraju, S., Blain, J., Gogol, K., Zhao, L., Hartley, R.C., Karlsson, C.A., Staker, B.L., Edwards, T.E., Stewart, L.J., Myler, P.J., Clare, M., Begley, D.W., Horn, J.R., Hagen, T.J.
Bioorg.Med.Chem.Lett.