CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family ATP-dependent Clp protease proteolytic subunit

Enzyme Information

3.4.21.92
Endopeptidase Clp.
based on mapping to UniProt Q83DJ2
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
-!- Belongs to peptidase family S14.

UniProtKB Entries (1)

Q83DJ2
CLPP_COXBU
Coxiella burnetii RSA 493
ATP-dependent Clp protease proteolytic subunit

PDB Structure

PDB 3Q7H
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the ClpP subunit of the ATP-dependent Clp Protease from Coxiella burnetii
Anderson, S.M., Wawrzak, Z., Gordon, E., Hasseman, J., Anderson, W.F., Savchenko, A., Center for Structural Genomics of Infectious Diseases (CSGID)
To be Published