CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family

Enzyme Information

1.8.1.5
2-oxopropyl-CoM reductase (carboxylating).
based on mapping to UniProt Q56839
2-mercaptoethanesulfonate + acetoacetate + NADP(+) = 2-(2-oxopropylthio)ethanesulfonate + CO(2) + NADPH.
-!- Also acts on thioethers longer in chain length on the oxo side, e.g. 2-oxobutyl-CoM, but this portion must be attached to CoM (2-mercaptoethanesulfonate); no CoM analogs will substitute. -!- Forms component II of a four-component enzyme system (comprising EC 4.4.1.23 (component I), EC 1.8.1.5 (component II), EC 1.1.1.268 (component III) and EC 1.1.1.269 (component IV)) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.

UniProtKB Entries (1)

Q56839
XECC_XANP2
Xanthobacter autotrophicus Py2
2-oxopropyl-CoM reductase, carboxylating

PDB Structure

PDB 3Q6J
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for carbon dioxide binding by 2-ketopropyl coenzyme M oxidoreductase/carboxylase.
Pandey, A.S., Mulder, D.W., Ensign, S.A., Peters, J.W.
Febs Lett.